5-HT4 Receptors in the Brain and Periphery by Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)

By Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)

This ebook presents a accomplished, up to date evaluation of the distribution, pharmacology and body structure of crucial 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes express a different pharmacology, distribution and serve as, of which the 5-HT4 receptor has been some of the most intensively studied lately, either from a easy study point of view and as a objective for novel therapeutics.

Show description

Read Online or Download 5-HT4 Receptors in the Brain and Periphery PDF

Similar nonfiction_9 books

High-Power Diode Lasers: Fundamentals, Technology, Applications: With Contributions by Numerous Experts

Tools of layout and fabrication of high-power diode lasers utilizing confirmed semiconductor applied sciences are offered in a complete model making this publication a useful resource of data for all scientists and engineers designing laser structures and utilising the laser as a competent and monetary instrument in a mess of environments.

Overweight and the Metabolic Syndrome: From Bench to Bedside

This quantity examines the matter of the obese person and the metabolic syndrome from the laboratory bench to the bedside. sincerely, translating the findings we make within the laboratory to the betterment of humankind is a crucial venture. parts the place simple technology is making vital contributions to the issues linked to metabolic syndrome are illustrated within the chapters on Neuroendocrine regulate of nutrients consumption, present perspectives of the fats cellphone as an Endocrine mobile: Lipotoxicity, and Ectopic fats and Metabolic Syndrome.

Defence Industry Applications of Autonomous Agents and Multi-Agent Systems

Safety and defense similar purposes are more and more being tackled by way of researchers and practioners utilizing applied sciences built within the box of clever Agent examine. This ebook is a suite of modern refereed papers drawn from workshops and different colloquia held in a variety of venues all over the world within the final years.

Additional info for 5-HT4 Receptors in the Brain and Periphery

Sample text

Br J Pharmacol1994; 113:12oP. 73· Gale JD, Green A, Darton J et al. GR125487: a 5-HT4 receptor antagonist with a long duration of action in vivo. Br J Pharmacol1994; 113:119P. 74· King DF, Gaster LM, Mulholland KR. 5-HT4 receptor antagonists. lnt Pat Appl1994; WO 94/27987. 75· Parker SG, HamburgerS, Taylor EM et al. SB203186, a potent 5-HT4 receptor antagonist, in porcine sinoatrial and human and porcine atriuim. Br J Pharmacol1993; 1o8:68P. 76. Wyman PA, Gaster LM, King FD et al. Azabicyclo indole esters as potent 5-HT4 receptor antagonists.

0 aReference 70. bAntagonism of 5-HT induced relaxation of rat, carbachol contracted esophagus muscularis mucosae. cpartial agonist. 12. SAR o/2-benzyloxyaryl ketone S-HT4 receptor antagonists a 0 Cl~ u,N I-"' ~x N,R ~ X pKt,C pK;b compd. 3 •Reference 70. bDisplacement of [3H]GR 113808 from guinea-pig striatal membranes. CAntagonism of 5-HT mediated relaxation of rat, carbachol contracted esophageal muscularis mucosae. 13. SAR of benzodioxanyl ketone 5-HT4 receptor antagonists a 0 compd. 0 "Reference 71.

So s-HT4 Receptors in the Brain and Periphery activation via the stimulation of cAMP production. The 5- HT 4 receptor is a member of this cyclase stimulatory serotonin receptor set. 12' 22 Both s-HT640 and 5-HT7 receptors 7•34•44 A7>48 are also coupled to stimulation of adenylate cyclase. Although one of the early subtypes to be characterized pharmacologically, the 5- HT 4 receptor was the last to be cloned. Cloning of the Rat 5-HT4 Receptor In order to clone the s-HT 4 receptor, rat brain eDNA was used as a template for PCR amplification with two degenerate oligonucleotide primers derived from the third and fifth transmembrane (TM) domains which are highly conserved in serotonin receptors.

Download PDF sample

5-HT4 Receptors in the Brain and Periphery by Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)
Rated 4.68 of 5 – based on 43 votes