Advances In Biochemical Engineering Biotechnology. Thermal by N/a

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50 . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 High Resolution Thin-Film Thermistors . . . . . . . . 2 Miniaturized Enzyme Thermistors . . . . . . . . . . 3 Integrated Thermopiles . . . . . . . . . . . . . 62 Advances in Biochemical Engineering / Biotechnology, Vol. 64 Managing Editor: Th. Scheper © Springer-Verlag Berlin Heidelberg 1999 36 F. Lammers · Th. 4 Bio-Thermochips . . . . . . . . . . . .

1985). Mecklenburg et al. (1993) used the LOD/LDH/CAT-system for an insulin-TELISA. Here, an amplification factor of about 10 was observed. Nevertheless, the cycling system is expensive, complicated and difficult to reproduce (Lammers, 1996). Especially for TELISA procedures, an optimized substrate for peroxidase labeled antibodies was developed. The substrate (2 mmol/l H2O2 and 2 mmol/l aminoantipyrine) causes a similar TELISA sensivity to that of the LOD/LDH/CAT cycle but is much easier to use, cheaper and very reproducible (Lammers, 1996).

3 Integrated Thermopiles . . . . . . . . . . . . . 62 Advances in Biochemical Engineering / Biotechnology, Vol. 64 Managing Editor: Th. Scheper © Springer-Verlag Berlin Heidelberg 1999 36 F. Lammers · Th. 4 Bio-Thermochips . . . . . . . . . . . . . . . 5 Compact Multichannel Enzyme Thermistors . . . . . . . 63 6 Conclusions . . . . . . . . . . . . . . . . 64 7 References . . . . . . . . . . . . . . . . . 64 1 Introduction Over the last two decades, great enthusiasm has been observed in biosensor research.

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Advances In Biochemical Engineering Biotechnology. Thermal by N/a
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