Advances in DNA Damage and Repair: Oxygen Radical Effects, by Steven Akman, Regen Drouin, Gerald Holmquist (auth.), Miral

By Steven Akman, Regen Drouin, Gerald Holmquist (auth.), Miral Dizdaroglu, Ali Esat Karakaya (eds.)

Damage to DNA by means of either exogenous and endogenous assets is more and more considered as hugely very important within the initiation and development of melanoma and within the occurance of alternative pathological occasions. DNA harm because of reactive oxygen-derived species, also known as oxidative DNA harm, is so much the widespread sort encountered via cardio cells. Mechanistic reports of carcinogenesis point out a huge position of this kind of harm to DNA. there's additionally robust facts to help the position of oxidative DNA harm within the getting older method. DNA harm is hostile in vivo through fix structures. If now not repaired, DNA harm could lead to hazardous organic outcomes. for this reason, the fix of DNA harm is considered one of many crucial occasions in all existence kinds. lately the sector of DNA fix has flourished as a result of new findings on DNA fix mechanisms and the molecular foundation of melanoma. a close wisdom of mechanisms of DNA harm and service, and the way person fix enzymes functionality could lead on to manipulation of DNA fix in cells and eventually to a rise of the resistence of human cells to DNA-damaging brokers. This quantity covers the newest devlopments during this learn box and comprises contributions from scientists operating within the fields of biochemistry, molecular biology, enzymology, biomedical technology, and radiation biology.

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Circumventing potential prooxidant action could contribute to increased protective ability of dietary antioxidants towards susceptible substrates. For example, proteins protect DNA against the prooxidant actions of some flavonoids and polyphenolic compounds in vitro (reviewed in Aruoma 1994). 7. IN VIVO IMPLICATIONS OF PROOXIDANT ACTIONS The interaction between food additives and nutrient components within the food matrix on the one hand, coupled with other interactions when the food and plant materials are consumed, is an area of current interest.

1. Aruoma, and B. Halliwell (1992). Stimulation of lipid peroxidation and hydroxyl radical generation by the contents of human atherosclerotic lesions, Biochem. J. 286: 901-905. 1. St. Angelo (1992). Lipid Oxidation in Food. American Chemical Society, Series 500, Washington. R. A. Priitz (1987). Copper-catalyzed DNA damage by ascorbate and hydrogen peroxide: kinetics and yield. Free Rad. Bioi. Med. 3: 97-105. T. B. M. Kuwabra, TA. S. Sigman (1989). Nuclease activity of I, 10-phenanthroline-copper: kinetic mechanism, J.

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Advances in DNA Damage and Repair: Oxygen Radical Effects, by Steven Akman, Regen Drouin, Gerald Holmquist (auth.), Miral
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