An Introduction to Protein Informatics by Karl-Heinz Zimmermann

By Karl-Heinz Zimmermann

Protein informatics is a more moderen identify for an already present self-discipline. It encompasses the strategies utilized in bioinformatics and molecular modeling which are with regards to proteins. whereas bioinformatics is principally all in favour of the gathering, association, and research of organic information, molecular modeling is dedicated to illustration and manipulation of the constitution of proteins.

Protein informatics calls for vast must haves on laptop technological know-how, arithmetic, and molecular biology. The technique selected the following, permits a right away and fast take hold of at the topic ranging from easy wisdom of set of rules layout, calculus, linear algebra, and chance theory.

An advent to Protein Informatics, a qualified monograph will give you the reader a entire advent to the sphere of protein informatics. The textual content emphasizes mathematical and computational how to take on the vital difficulties of alignment, phylogenetic reconstruction, and prediction and sampling of protein constitution.

An advent to Protein Informatics is designed for a qualified viewers, composed of researchers and practitioners inside of bioinformatics, molecular modeling, set of rules layout, optimization, and trend reputation. This publication can also be appropriate as a graduate-level textual content for college kids in computing device technology, arithmetic, and biomedicine.

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The number of genes of a genome is referred to as g-value. 11. gene gene Sequence of genes of a genome. The size of a genome is termed c- value and is measured by the number of base pairs (bp) of the corresponding DNA molecule. The genome size increases with the complexity of the organisms. For instance, funghi and algae have cvalue of about 108 bp, while birds have c-value of more than 109 bp. There are notable exceptions comprising the c-value paradox: The c-value of flower plants varies from 5 .

22. The backbone structure of a-helix. 6 residues per turn. The left-handed a-helix differs from the right-handed a-helix by the dihedral angles ¢ and 'IjJ. They have the same absolute values but with opposite sign. The left-handed a-helix is sterically possible but not energetically favorable, since the side chains are in close contact with the backbone. Sheets A {3-sheet consists of strands that aggregate side by side forming hydrogen bonds between the carbonyl oxygens and the nitrogen groups NH of the backbone.

A prokaryotic ribosome consists of two subunits, with the molecular weight of 930 kDa and 1590 kDa. Eukaryotic ribosomes also consist of two subunits but are larger and more complex than prokaryotic ribosomes. A ribosome starts its work by binding to the promoter of the mRNA molecule. The promoter is a sequence of 5 to 9 nucleotides and lies upstream of the start codon. Then the ribosome moves downstream to the start codon of the mRNA 42 CHAPTER 2: BIOSYNTHESIS A' 3' C C A 5'G . C G'C U'A G'C stem G' C A•U Tleg UU .

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An Introduction to Protein Informatics by Karl-Heinz Zimmermann
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