By R. Cameron, G. Feuer (auth.), Professor Ross G. Cameron M.D., Ph.D., Professor George Feuer Ph.D., C. Med. Sci. (eds.)
Apoptosis is an engaging notion for the elemental scientist. this isn't merely a result of multifaceted number of proposed and came across mechanisms, yet simply because apoptosis represents a basic pathway for telephone renewal. The learn of apoptosis has led to an array of discoveries on sign transduc tion and downstream results that experience facilitated and complicated many fields in biology, together with study on melanoma and different illnesses. hence, the apoptotic method might be seen because the biggest attempt of the clinical neighborhood to appreciate how cells paintings and tissues gather or rework. the main direct final result of this gathered wisdom is a better realizing of ailment and pathological mechanisms. the result of those efforts should be major contributions to healthiness and the adoption of recent, by no means expected, healing methods. This ebook represents the summation of substantial attempt from an important workforce of participants from around the globe in addition to from its editors. during this style, many viewpoints were amassed and SUbjected to thorough educational dialogue. The strategies contained during this medically very important quantity will stimulate and renew the tips of scientists and certainly, will generate extra paintings to strengthen organic wisdom even extra. The emphasis of this quantity cements what has been verified, provides what has now not been explored absolutely, and creates a fertile floor for extra hypotheses that may bring about a extra whole figuring out of the apoptotic process.
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Extra resources for Apoptosis and Its Modulation by Drugs
Lab Invest 33:478-490 Bennett RE, Harrison MW, Bishop CT, Searle J, Kerr JFR (1984) The role of apoptosis in atrophy of the small gut mucosa produced by repeated administration of cytosine arabinoside. J Path 142:259-263 Bernuau D, Feldmann G, Degott C, Gisselbrecht C (1981) Ultrastructural lesions of bile ducts in primary biliary cirrhosis. A comparison with the lesions observed in graft versus host disease. Human PathoI12:782-793 Bhathal PS, Gall JAM (1985) Deletion of hyperplastic biliary epithelial cells by apoptosis following removal of the proliferative stimulus.
FEUER immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover. J Cell Bioi 133:335-343 Galili V, Leiserowitz R, Moreb J, Gamliel H, Gurfel D, Pollack A (1982) Metabolic and ultrastructural aspects of the in vitro lysis of chronic lymphocytic leukemia cells by glucocorticoids. Cancer Res 42:1433-1440 Galli C, Piccini A, Ciotti MT, Castellani L, Calisgano P, Zaccheo D, Tabaton M (1998) Increased amyloidogenic secretion in cerebellar granule cells undergoing apoptosis.
These substances included dimethylhydrazine, I-j3-d-arabinofurasonylcytosine (ara-C). The extent of apoptosis and subsequent cell death induced in proliferating tissues by these chemicals are not correlated with the rate of mitosis. Several cancer-chemotherapeutic agents produce more apoptotic bodies than occur in physiological conditions in normal highly proliferative tissues. The mechanism of action of these substances has not yet been established. It may be associated with their action on DNA, causing damage and affecting DNA turnover and repair.
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