Biguanides

Read or Download Biguanides PDF

Similar chemistry books

Descriptive Inorganic Chemistry, Second Edition

This booklet covers the synthesis, reactions, and houses of components and inorganic compounds for classes in descriptive inorganic chemistry. It is appropriate for the one-semester (ACS-recommended) path or as a complement ordinarily chemistry classes. perfect for significant and non-majors, the publication contains wealthy graphs and diagrams to augment the content material and maximize studying.

Additional resources for Biguanides

Sample text

CN (I) (2) II NH In the presence of aniline hydrochloride, 1,3-diphenylguanidine hydrochloride is an additional product; its formation can be accounted for in four ways, but proceeds in fact exclusively according to equation (2) (669). p. 201--205 ~ (27% relative to phenylbiguanide) was formulated (669) as either 2,4-diphenylmelamine or 1,2diphenylisomelamine. The melting points (216--218 ~ and 254 ~ respectively) of these two melamines subsequently synthesised (375--377) clearly suggest that the by-product was 2,4-diphenylmelamine.

In the presence of sodium ethoxide, the intermediate is not formed, and the reaction affords 2-amino-4-anilino-s-triazine-6-carboxylic acid in one stage (642). 430 The Chemisfryof Biguanides The corresponding reaction of cyclohexylbiguanide has given comparable results (607). The primary intermediate was not identified but, as a basis for discussion, was formulated as the six-membered bridged carbonyl compound (CXXlI). NPh NII (CXXl) PhNH"C"//m---n=x,n ..... HN o ~ H O (CXVlrr) BY~_N COOH (cxx) CO I COOK (CXlX) N'HC6H.

Kurzer and E. D. Pitchfork Table 2. 05 I~ef. (177) (sag) {569) (37) (37) (544) (559) (569) (569) (56P) (569) (666) (666) (301) (569) (569) (194) (30 I) (801) (lg4) (/94) (194) (194) (194) (301) (301) (19d) (194) ( 777) (569) (569) (37) (37) (194) (569) (558) (558) (558) (9) a Although n o t specified in the papers, the values are h s t e d here as first acid dissociation constants, in view of their numerical values. b A p K value was not obtained for this compound because of its strong tendency to form mice/les, even in dilute solutions.

Download PDF sample

Biguanides
Rated 4.58 of 5 – based on 27 votes