Biocombinatorial Approaches for Drug Finding by M. A. Koch, H. Waldmann (auth.), W. Wohlleben, T. Spellig,

By M. A. Koch, H. Waldmann (auth.), W. Wohlleben, T. Spellig, B. Müller-Tiemann (eds.)

Genome- and proteome-based examine is producing an important bring up within the variety of to be had drug pursuits. Correspondingly there's an expanding desire for novel, different compounds, rather in response to typical compounds, as screening source. the aim of the Ernst Schering study starting place Workshop 51 used to be to supply a discussion board for an open alternate on views and barriers of biocombinatorial synthesis and the importance of this know-how for destiny drug discovery in mild of this problem. specialists from academia and supplied contributions overlaying: the importance of typical compounds for cutting-edge drug discovery; the underlying simple precept for the biosynthesis of hugely advanced compounds; and the scope and barriers of combinatorial biosynthesis concerning formation, id, optimisation, isolation and production of novel biologically energetic entities.

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Extra resources for Biocombinatorial Approaches for Drug Finding

Sample text

Ketoreductases . . . . . . . . . . . . . Dehydratases and Enoylreductases . . . . . . . Thioesterases . . . . . . . . . . . . . . PKS Structure . . . . . . . . . . . . . . A Note of Caution . . . . . . . . . . . . Interdomain and Intermodular Linkers . . . . . . Interprotein `Docking Domains' . . . . . . . . Combinatorial Biosynthesis: How to Proceed? . . . Conclusions . . . . . . . . . . . . . . References .

Microbiol Ecol 45:362±372 Metsa-Ketela M, Halo L, Munukka E, Hakala J, Mantsala P, Ylihonko K (2002) Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species. Appl Environ Microbiol 68: 4472±4479 Monciardini P, Cavaletti L, Schumann P, Rohde M, Donadio S (2003) Conexibacter woesei gen. , sp. , a novel representative of a deep evolutionary line of descent within the class Actinobacteria.

2002). Sources of Polyketides and Non-Ribosomal Peptides 29 In addition, a strain representative of a deep evolutionary line of descent within the class Actinobacteria was fortuitously isolated during a routine actinomycete isolation programme (Monciardini et al. 2003). We thus reasoned that many uncultured actinomycetes were likely to exist in soil, and with the appropriate tools and patience they could eventually be domesticated. In general terms, isolation of uncultured actinomycetes could be attempted in two ways.

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Biocombinatorial Approaches for Drug Finding by M. A. Koch, H. Waldmann (auth.), W. Wohlleben, T. Spellig,
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