What's Wrong With My Mouse?: Behavioral Phenotyping of by Jacqueline N. Crawley PhD

By Jacqueline N. Crawley PhD

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1999). In other examples, null mutants for the p53 tumor suppressor gene exhibited resistance to kainate-induced neuronal cell death when bred into a C57BL/6J background but lacked resistance to kainate-induced BREEDING STRATEGIES 27 neuronal cell death when bred into a 129/SvEMS background (Schauwecker and Steward, 1997). Decreased sensitivity to the sedative-hypnotic effects of ethanol, and failure to develop chronic tolerance to ethanol, were discovered in γ-protein kinase C knockout mice bred onto a mixed C57BL/6J × 129/SvJ background and backcrossed into a C57BL/6J × 129/SvEvTac background.

Tissuespecific conditional mutations allow the investigator to insert the mutation only into specific cell types. Conditional mutations solve two problems: (1) lack of control over the integration site of a transgene into the chromosome and (2) ubiquity of a knockout mutation throughout the body. Linking the transgene to a tissue-specific promoter limits the site of integration to the chromosomal locus homologous with the specific promoter. Linking a knockout to a tissue-specific promoter ensures that the modified DNA construct is expressed only in tissues that normally express that promoter gene.

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What's Wrong With My Mouse?: Behavioral Phenotyping of by Jacqueline N. Crawley PhD
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